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Using single-molecule localization microscopy in living and fixed cells, we studied the
spatiotemporal genome remodeling of key pluripotency genes during the mouse
pluripotency transition. In living mouse embryonic stem cells and at the early stages of
epiblast specification, we examined the chromatin structure at the nanoscale level around
the Oct4 locus. We imaged both nascent RNA and transcription factor kinetics.
Garate et al. Nucleic Acids Research, 2024, June 8