Our paper on Parkinson’s disease therapy is in press in EBioMedicine (http://www.ebiomedicine.com/article/S2352-3964(16)30151-7/abstract), a new online journal supported by Cell press and Lancet. A definitive therapy for Parkinson’s disease is not available. In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson’s disease. These transplanted cells fused with neurons and glial cells of the recipient mice. Four weeks after transplantation, the hybrids acquired features of mature astroglia, secreted Wnt1, and functionally ameliorated dopaminergic neuron loss. Current cell therapy approaches are being pursued in the striatum with the aim to increase dopamine levels. Here we show that the loss of dopaminergic neurons can be protected against by direct actions in the substantia nigra.
Altarche-Xifro W, Di Vicino U, Muñoz-Martin MI, Bové J, Vila M and Cosma MP (2016). Functional rescue of dopaminergic neuron loss in Parkinson’s disease mice after transplantation of hematopoietic stem and progenitor cells, EBioMedicine, in press.