The Chemokine Receptors Ccr5 and Cxcr6 Enhance Migration of Mesenchymal Stem Cells into the Degenerating Retina
Inadequate migration and integration of transplanted cells into the retina limit the efficacy of cell therapy approaches. We found that chemokines released from the degenerating retina can drive migration of transplanted stem cells over-expressing Ccr5 and Cxcr6 receptors, thereby resulting in rescue of retinal degeneration.
Pesaresi et al. Molecular Therapy 2020