Our work on genome folding combining super-resolution microscopy and advance computational model has been published in Nature Structural & Molecular Biology. We have developed a strategy called MiOS (Modelling immuno-OligoSTORM) that allows to generate models of gene folding reaching nucleosome resolution. With MiOS we can explore how gene shape dynamically changes across cell types in health and disease.
Maria Victoria Neguembor et al. October 2022 Nature Structural & Molecular Biology
Cartoon representation of MiOS.
MiOS is like a 3D printer that processes imaging and sequencing data to generate 3D models of gene folding” Image by Laura Martin