The Master Regulator protein BAZ2B can reprogram human hematopoietic lineage-committed progenitors into a multipotent state.
Arumugam et al. Cell Reports 2020
We used reverse-engineered networks to elucidate the molecular mechanism of cell-fusion mediated reprogramming of B lymphocytes to hematopoietic stem cell-like state. BAZ2B was identified as a Master Regulator that can reprogram human lineage-committed progenitors to multipotent hematopoietic cells, thus enhancing their stemness and long-term engraftment.