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Our work published in Cell last year ( Ricci MA, Manzo C, García-Parajo M, *Lakadamyali M, and *Cosma MP (2015). Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo. Cell, *co-last authors. Nominated F1000Prime 2015) has been selected to be among the best 8 research in Spain. In collaboration with the group of Melike Lakadamyali using super resolution microscopy we dissected out the nanoscale organisation of the nucleosome assembly in a variety of somatic and stem/ reprogrammed cells. We discovered that nucleosomes are arranged into discrete groups, which we called ‘nucleosome clutches’ (in analogy with egg clutches) and not in a regular hierarchical structure, as it was believed for a long time and is reported in textbooks. Nucleosome median number and clutch compaction correlate closely with cellular state.

Picture by David Airob, La Vanguardia

 

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Wednesday, 23 March 2016 by

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