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Chromatin organization and gene expression are interdependent. Previously, our group had showed that nucleosomes form groups, termed clutches, whose size correlates with cell state. 

In this paper, Alvaro, together with Jason Otterstrom, carried out 2-color super-resolution microscopy to image core histones and DNA at nanoscale resolution.

They identified the “clutch DNA” as the DNA whose compaction is dependent on the clutch. Moreover, they studied how the epigenetic state of the clutch alters the radius of the clutch DNA.

These results provide novel insights into chromatin organization at the nanoscale level and show how the clutches affect DNA packaging.

 

 Castells-Garcia et al. 2019 Nucleic Acids Research 

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz593/5530308?searchresult=1

Happy to be interviewed in the blog Research in Barcelona and be able to share my views on my work and on research in general. You can read the interview here

Martina, Ruben and Pia discuss in this State-of-the-Art Review of The FEBS Journal the latest advances and applications of in vivo reprogramming strategies for regenerative medicine with a special focus on dedifferentiation, transdifferentiation and cell fusion processes. Cover of The FEBS Journal

Christmas celebration 2018 part I…..

Friday, 14 December 2018 by

Christmas Lunch 2018 and Secret Santa Gift 🙂

Cosma lab at the Open Day 2018!

Friday, 14 December 2018 by

Laura, Martina, Ruben and Victoria participated in the 2018 edition of the PRBB Open Day explaining the current lines of research in the lab, giving outreach seminars and doing experiments with kids!

https://www.prbb.org/openday

btf

dav

sdr

We are looking for a highly motivated research scientist with expertise in biology, biomedicine, physics or related disciplines. The candidate will hold a PhD and will have experience with cell culture and microscopy.

More info here!

 

 

 

 

 

 

In GenStorm our goal is to combine high resolution microscopy with molecular modeling techniques. With this multidisciplinary approach we aim to understand how genes are organized within the cell nucleus and how this affects their function. The project is coordinated by Victoria Neguembor (Cosma lab at CRG) and Pablo Dans (Orozco lab at IRBB).

 

BIST awards three multidisciplinary projects for the Ignite Program’s second phase

Our work on PoSTAC (Polycistronic SunTAg modified CRISPR) has been published in Nucleic Acids Research.

PoSTAC is a gene visualisation tool that combines CRISPR/dCas9 with SunTag labeling and polycistronic vectors. PoSTAC enables live cell and super-resolution imaging of multiple genes with high spatiotemporal resolution and high sensitivity.

 

 

Neguembor et al. 2017 Nucleic Acids Research 

Christmas Celebration 2017!!

Thursday, 14 December 2017 by

 

 

 

 

 

 

 

 

 

 

    Christmas Lunch 2017 and Secret Santa Gift 🙂

 

 

Ruben Sebastian Perez, a master student in our lab, has got the second place in the “Tell it to your parents” contest  organized by Sociedad Española de Bioquímica y Biología Molecular (SEBBM).

Master students and bachelor students had to make videos for the general audience, in which they explain different Research concepts in the simplest way possible.

Below you can get a link to Ruben’s video : “A decade of iPS cells”

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